The ICIST conference was hosted by the largest technical university in the Baltic States - Kaunas University of Technology (Lithuania). ICIST 2021 aimed to bring together researchers, engineers, developers and practitioners from academia and industry working in all major and interdisciplinary fields of information systems, business intelligence, software engineering and information technology applications. In 2021, the Conference was held in Kaunas on October 14-16, 2021 in a mixed way.